respiratory parameters from conscious restrained animals: double-chamber / head-out plethysmography

respiratory parameters from conscious restrained animals:
double-chamber / head-out plethysmography

respiratory parameters from conscious restrained animals:
double-chamber / head-out plethysmography

The double-chamber plethysmograph (dcp) measures respiratory parameters in a conscious restrained subject, including airway resistance and conductance.

Different sizes of plethysmograph exist to study mice, rats or guinea pigs.

key features

• measurement of nasal and thoracic flows
• no surgery, no anesthetic
• can be used with body chamber only (head-out configuration)
• conical restrainer for less stressed animal and easier manipulation
• can be used for long-term measurements and chronic studies in same animals
• can be used to screen large number of subjects

standard equipment (no options)

• double-chamber plethysmograph
• ventilation pump
• 2 dpt differential pressure transducers
• amplifier
• interface box
• acquisition card
• iox2 software with the DCRF analyzer

parameters

• inspiratory time (TI)
• expiratory time (TE)
• peak inspiratory flow (PIF)
• peak expiratory flow (PEF)
• tidal volume (TV)
• expired volume (EV)
• relaxation time (RT) - time taken to expire a user-defined percentage of tidal volume
• minute volume (MV)
• breathing rate
• end-inspiratory pause (EIP)
• end-expiratory pause (EEP)
• pause and enhanced pause - indicators of bronchoconstriction
• specific airway resistance (SRaw)
• specific airway conductance (GGaw)
• mid-expiratory flow (EF50)

options

• aerosol generation & delivery
• pulmonary pressure (implant)
• resistance/compliance in conscious animals
• cardiorespiratory studies

head-out configuration

The head-out configuration is identical to the standard configuration described above except that there is no head chamber.

Of course the collar seal is still applied, so that the body chamber remains airtight. With only a thoracic signal, all parameters can be obtained except for specific airway resistance (SRaw) and specific airway conductance (Sgaw).

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