who uses our solutions for researchers studying pulmonary function?

Respiratory Research 2010, 11:82, Karim H Shalaby¹, Leslie G Gold2, Thomas F Schuessler², James G Martin¹ and Annette Robichaud², ¹Meakins Christie Laboratories, McGill University, Montreal, Québec, Canada and ²SCIREQ Scientific Respiratory Equipment Inc., Montreal, Québec, Canada, 2010

Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness

This is a publication that describes the use of the negative pressure-driven forced expiratory manoeuvres (NPFE) and the forced oscillation technique (FOT). The objective of this study was to obtain NPFE and FOT measurements at baseline and following bronchoconstriction from a single cohort of mice using a combined system in order to assess both techniques through a refined approach.

Scireq flexiVent system.

Environmental Toxicology and Pharmacology 29 (2010) 173–182, Baher Fahmy^a,1, Liren Ding^a,2, Dahui You^a, Slawo Lomnicki^b, Barry Dellinger^b, Stephania A. Cormier^a,*,^a Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA, ^b Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA, 2010

in vitro and in vivo assessment of pulmonary risk associated with exposure to combustion generated fine particles

This is a publication that describes the use of the inExpose system to perform nose-only aerosol exposures of rats and then the use of the flexiVent system for assessing the resulting lung function changes. In particular, they assess particle deposition using fluorescent microspheres and conclude that the inExpose provides relevant and reliable exposures consistent with deposition profiles of airborne particles in human lungs.

Journal of Pharmacological and Toxicological Methods 60 117-129, Annie Delaunois a, Paul Dedoncker a, Etienne Hanon b, Michel Guyaux a,⁎, a Department of Non Clinical Development, Non Clinical Safety Pharmacology Group, UCB Pharma SA, Belgium, b Department of CNS Research, Biological Data Analysis, UCB Pharma SA, Belgium, 2009

repeated assessment of cardiovascular and respiratory functions using combined telemetry and whole-body plethysmography in the rat

All the cardiovascular and respiratory data were acquired simultaneously in real time and transferred into a data analysis system from emka TECHNOLOGIES (iox software)

The Journal of Experimental Medicine, Y. Chvatchko, A. J. Hoogewerf, A. Meyer, S. Alouani, P. Juillard, R. Buser, F. Conquet, A. E.I. Proudfoot, T. N.C.Wells, C. A. Power, Serono Pharmaceutical Research Institute, Switzerland, May 2000

a key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock

study performed on mice to investigate the in vivo role of CC chemokine receptor 4, generating CCR4-deficient mice by gene targeting.

poster presented by Notox, Netherlands, at the meeting of the Association of Inhalation Toxicologists, Dublin, Ireland, Autumn 2008 and the Society of Safety Pharmacology meeting, Madison, WI, USA, september 2008

a head-out plethysmography set-up for respiratory safety assessment after oral or intravenous and during inhalatory administration of a drug or chemical

study performed on ten male rats

• graphs of pneumotachograph signals recorded by the data acquisition software IOX.

Clinical & Experimental Immunology, X. Havaux, A. Zeine, A. Dits and O. Denis, Université Catholique de Louvain and Pasteur Institute of Brussels, Brussels, Belgium, October 2004

a new mouse model of lung allergy induced by the spores of Alternaria alternata and Cladosporium herbarum molds

study performed on mice to demonstrate that A. alternata and C. herbarum spores are immunogenic when injected into BALB/c mice, and induce the production of specific IgM and IgG1 antibodies and strongly increase IgE serum levels.

Journal of Applied Physiology, T. D. Flandre, P. L. Leroy, D. J-M. Desmecht, University of Liège, Belgium, November 2002

effect of somatic growth, strain, and sex on double-chamber plethysmographis respiratory function values in healthy mice

study performed on mice

• comparison of pleural catheterization, LFOT (Low-frequency Forced Oscillation Technique), single-chamber plethysmography and double-chamber plethysmogaphy
• photograph of the double-chamber plethysmograph from emka TECHNOLOGIES.

American journal of respiratory cell and molecular biology, A. J.M. Van Oosterhout, B. Van Esch, G. Hofman, C. L. Hofstra, I. Van Ark, F. P. Nijkamp, M. L. Kapsenberg, H. F.J. Savelkoul, F. R. Weller, Utrecht University, Erasmus University of Rotterdam and Academic Medical Center of Amsterdam, The Netherlands, February 1998

allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness associated with decreased IL-4 production by lymphicytes in a murine model of allergic asthma

study performed on mice to investigate whether allergen immunotherapy is effective in a murine model with immunologic and pathophysiologic features reminiscent of allergic asthma.

The Journal of Neuroscience, H. Burnet, M. Bévengut, F. Chakri, C. Bou-Flores, P. Coulon, S. Gaytàn, R. Pàsaro, G. Hilaire, Centre National de la Recherche Scientifique, Marseille, France and Universitad de Sevilla, Spain, July 2001

altered respiratory activity and respiratory regulations in adult monoamine oxidase a-deficient mice

study performed on mice to know whether alterations respiratory network maturation at birth occur only transiently or induce persistent respiratory dysfunction during adulthood.

The Journal of Experimental Medicine, C. M. Lloyd, T. Delaney, T. Nguyen, J. Tian, C. Martinez-A, A. J. Coyle, J-C. Gutierrez-Ramos, Millenium Pharmaceuticals Inc, Cambridge, USA and Université autonome de Madrid, Spain, January 2000

CC chemokine receptor (CCR)3/ eotaxin is followed by CCR4/ monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo

study performed on mice to address the functional role of CCR3/eotaxin and CCR4/MDC during the in vivo recruitment of Th2 cells.

The Journal of Experimental Medicine, A. J. Coyle, C. Lloyd, J. Tian, T. Nguyen, C. Erikkson, L. Wang, P. Ottoson, P. Persson, T. Delaney, S. Lehar, S. Lin, L. Poisson, C. Meisel, T. Kamradt, T. Bjerke, D. Levinson, J. C. Gutierrez-Ramos, Millenium Pharmaceuticals Inc, Cambridge, USA; Astra Draco Lund, Sweden and Deutsches Rheumaforschung Zemtrum, Universitatsklinikum Charite, Berlin, Germany, October 1999

crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immunne responses

study performed on mice to demonstrate an important role of T1/ST2 in Th2-mediated inflammatory responses and suggest that T1/ST2 may prove to be a novel target for the selective suppression of Th2 immune responses.

The Journal of Experimental Medicine, S. Tsuyuki, J. Tsuyuki, K. Einsle, M. Kopf, A. J. Coyle, Ciba-Geigy Ltd., Basel, Switzerland, R&D Dept. Kissei Pharmaceutical Co. Ltd., Matsumoto, Japan and Basel Institute for Immunology, Basel, Switzerland, May 1997

costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness

study performed on mice to determine whether CD28/CTLA-4 ligands are required for allergen-induced eosinophil accumulation and the production of Th2 cytokines.

American Journal of Respiratory Cell and Molecular Biology, D. T. Deurloo, B. C.A.M. van Esch, C. L. Hofstra, F. P. Nijkamp, A. J.M. van Oosterhout, Utrecht University, The Netherlands, July 2001

CTLA4-IgG reverses asthma manifestations in a mild but not in a more "severe" ongoing murine model

study performed on mice to investigate whether CTLA4-Ig can reverse established asthma manifestations in a novel murine model of ongoing disease.

The Journal of Experimental Medicine, A. Mathew, J. A. MacLean, E. DeHaan, A. M. Tager, F. H.Y. Green, A. D. Luster, Harvard Medical School boston, University of Calgary, USA, May 2001

signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation

study performed on mice to isolate the role of Stat6 in regulating Th2 cell trafficking and effector function from its role in Th2 cell differentiation.

Journal of Applied Physiology, L. L. Couëtil, F. S. Rosenthal, C. M. Simpson, Purdue University, Indiana, USA, 2000

forced expiration: a test for airflow obstruction in horses

study performed on nine horses to assess whether our method of inducing forced expiration detects small airway obstruction in them.

The Journal of Experimental Medicine, Y. Chvatchko, M. H. Kosco-Vilbois, S. Herren, J. Lefort, J-Y. Bonnefoy, Geneva Biomedical Research Institute, Switzerland and Institut Pasteur Paris, France, December 1996

germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge

study performed on mice to investigate the nature of the cell contributing in the development and maintenance of airway hyperreactivity and histopathology during allergic inflammation remains unclear.

American Journal of Respiratory Cell and Molecular Biology, P. W. Hellings, A. Kasran, Z. Liu, P. Vandekerhove, A. Wuyts, L. Overbergh, C. Mathieu, J. L. Ceuppens, University of Leuven, Belgium, July 2002

interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma

study performed on mice to investigated the involvement of IL-17 in the bronchial influx of neutrophils in experimental allergic asthma.

Toxicological Sciences, J. A.J. Vanoirbeek, C. Mandervelt, A. R. Cunningham, P. H.M. Hoet, H. Xu, H. M. Vanhooren, B. Nemery, Katholieke University of Leuven, Belgium and Louisiana University, USA, August 2003

validity of methods to predict the respiratory sensitizing potential of chemicals: a study with a piperidinyl chlorotriazine derivative that caused an outbreak of occupational asthma

study performed on BALB/c mice to verify the sensitizing potential of piperidinyl chlorotriazine (PCT). Respiratory hyperreactivity was assessed following a novel protocol involving dermal sensitization and intranasal challenge, followed, after 24 h, by a methacholine challenge (using emka whole-body plethysmography), bronchoalveolar lavage, and histology.

British Journal of Pharmacology, C. Brown, M. Fezoui, W. M. Selig, C. E. Schwartz, J. Ellis, UCB Pharma Cambridge, Belgium, December 2003

antitussive activity of σ-1 receptor agonists in guinea-pig

This study examined and compared the antitussive activity of DEX and various putative σ receptor agonists in the guinea-pig citric-acid cough model.

ToxSci Advance Access, J. A.J. Vanoirbeek, M. Tarkowski, J. L. Ceuppens, E. K. Verbeken, B. Nemery, P. H. M. Hoet, University of Leuven, Belgium, May 2004

respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice

study performed on mice to predict the potential of low molecular weight chemicals to cause asthma.

The Journal of Thoracic and Cardiovascular Surgery , S. Fortier; R. G. DeMaria; Y. Lamarche; O. Malo; A. Denault; F. Desjardins; M. Carrier; L. P. Perrault, Montreal Heart Institute, Quebec, Canada and CHU Arnaud de Villeneuve, Montpellier, France, September 2003

inhaled prostacyclin reduces cardiopulmonary bypass-induced pulmonary endothelial dysfunction via increased cyclic adenosine monophosphate levels

study performed on Landrace swine to demonstrate that inhaled prostacyclin, a selective pulmonary vasodilator prostaglandin, prevents pulmonary arterial endothelial dysfunction induced by cardiopulmonary bypass.

Kloek, I. Van Ark, g. Folkerts, f. De Clerck, N. Bloksma, F.P. Nijkamp, Utrecht University, The Netherlands, Janssen Research Foundation, Beerse, Belgium, 2004

modulation of hyperresponsiveness by glutathione in a murine in vivo model of allergic asthma

study performed on mice to address the question to what extent nebulization of GSH or GSH-precursors could counteract the development of airway inflammation and AHR in an in vivo murine model of asthma.

Veterinary Research, D. J. Halloy, S. Bouhet, I. P. Oswald, M. Goret-Nicaise, M. Kobisch, J. Mainil, P. G. Gustin, University of Liège, Belgium, January 2004

pathophysiological changes occurring during Escherichia coli endotoxin and Pasteurella multocida challenge in piglets: relationship with cough and temperature and predicitive value for intensity of lesions

study performed on piglets to evaluate the relationship between the cough, body temperature, pulmonary inflammatory process, functional changes and lung lesions during the course of a pneumonic pasteurellosis model.

Immunology, M. S. Arredouani, A. Kasran, J. A. Vanoirbeek, F. G. Berger, H. Baumann and J. L. Ceuppens, Gasthuisberg University Hospital, Catholic University of Leuven, Belgium, October 2004

haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo

study performed on mice to determine the effects of Hp on the release of pro- and anti-inflammatory cytokines following endotoxin stimulation and cytokine priming of human monocytes, as well as on the expression of CD14 antigen.

Bioorganic & Medicinal Chemistry, E. Keinan, A. Alt, G. Amir, L. Bentur, H. Bibi and D. Shoseyov, Technion, Israel Institute of Technology, Israël, September 2004

natural ozone scavenger prevents asthma in sensitized rats

study performed on rats to demonstrate that pulmonary inflammation in asthma involves a vicious circle of ozone production and recruitment of white blood cells, which produce more ozone.

The Journal of Immunology, I. Spik, C. Brénuchon, V. Angéli, D. Staumont, S. Fleury, M. Capron, F. Trottein, D. Dombrowicz, Institut Pasteur de Lille, France, December 2004

activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse

study performed on female mice to demonstrate that mouse eosinophils express both DP1 and DP2 and that PGD2 exerts in vitro chemotactic effects on eosinophils through DP2 activation.

Genes & Development, J. H. Reiling, E. Hafen, Universität Zürich, Switzerland, September 2004

the hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

study performed on Drosophila to show that scylla and charybdis, two homologous genes identified as growth suppressors in an EP (enhancer/promoter) overexpression screen, act as negative regulators of growth.